Atopic asthmatic subjects but not atopic subjects without asthma have enhanced inflammatory response to ozone
نویسندگان
چکیده
منابع مشابه
Effect of inhaled endotoxin on induced sputum in normal, atopic, and atopic asthmatic subjects.
BACKGROUND Inhalation of lipopolysaccharide (LPS) causes an inflammatory response in the lungs. To explore this response, inflammatory indices were measured in induced sputum from atopic asthmatic patients and compared with atopic and non-atopic subjects after inhalation of LPS. METHODS The effects of inhaled LPS (60 micrograms) or placebo (0.9% saline) were examined in a randomised, double b...
متن کاملAirway response to salbutamol: effect of regular salbutamol inhalations in normal, atopic, and asthmatic subjects.
This study was designed to determine whether resistance to the airway effects of the beta-agonist, salbutamol, would develop in three groups of subjects while taking large doses of inhaled salbutamol. Six normal non-atopic, six atopic non-asthmatic, and eight atopic asthmatic subjects were studied by an identical technique. The development of resistance was assessed from salbutamol dose-respons...
متن کاملCharacterisation of bronchoconstrictor responses to sodium metabisulphite aerosol in atopic subjects with and without asthma.
Inhalation of sodium metabisulphite is thought to induce bronchoconstriction by release of sulphur dioxide. We sought to establish the reproducibility of the airway response to inhaled sodium metabisulphite given in increasing doubling concentrations (0.3 to 160 mg/ml) to 13 asthmatic and five atopic non-asthmatic subjects and the contribution of cholinergic mechanisms to this response. In 15 o...
متن کاملThe T cell response to major grass allergens is regulated and includes IL-10 production in atopic but not in non-atopic subjects.
BACKGROUND The incidence of allergic diseases is increasing in industrialized countries and the immunological mechanisms leading to tolerance or allergy are poorly understood. Cytokines with suppressive abilities and CD4(+)CD25(+) regulatory T cells have been suggested to play a central role in allergen-specific responses. The aim was to determine whether major grass allergens induce production...
متن کاملRelationship between exposure to domestic allergens and bronchial hyperresponsiveness in non-sensitised, atopic asthmatic subjects.
BACKGROUND The effect of exposure to allergens not causing sensitisation in atopic asthmatic subjects has not previously been studied. A study was undertaken to assess the degree of asthma severity (measured by spirometry, airway reactivity and exhaled nitric oxide) in atopic asthmatic patients not sensitised to the domestic allergen to which they were exposed. METHODS Dust samples were colle...
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ژورنال
عنوان ژورنال: Journal of Allergy and Clinical Immunology
سال: 2010
ISSN: 0091-6749
DOI: 10.1016/j.jaci.2010.06.043